✦ LIBER ✦

Detection of microscopic melanoma metastases in sentinel lymph nodes

✍ Scribed by Lawrence L. Yu; Thomas J. Flotte; Kenneth K. Tanabe; Michele A. Gadd; A. Benedict Cosimi; Arthur J. Sober; Martin C. Mihm Jr.; Lyn M. Duncan

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 541 KB
Volume: 86
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19990815)86:4<617::aid-cncr10>3.0.co;2-s

No coin nor oath required. For personal study only.

✦ Synopsis

BACKGROUND.

Sentinel lymph node biopsy following radioisotope labeling is a recently developed, minimally invasive surgical staging procedure used in the management of primary cutaneous malignant melanoma. If histologic analysis reveals melanoma metastasis in the sentinel lymph node, completion lymphadenectomy is performed and adjuvant therapy considered. The routine pathologic assessment of the sentinel lymph node consists of bisecting the lymph node along its long axis and histologic examination of one hematoxylin and eosin-stained section of each cut surface.

METHODS.

In this study, the authors reexamined 235 sentinel lymph nodes reported as negative for melanoma metastasis following routine histologic examination, from 94 patients with American Joint Committee on Cancer (AJCC) Stage I and II cutaneous melanoma.

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