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Detection of micrometastatic tumor cells in bone marrow of breast carcinoma patients

✍ Scribed by S. Eva Singletary; Lillie Larry; Susan L. Tucker; Gary Spitzer

Book ID
102924259
Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
544 KB
Volume
47
Category
Article
ISSN
0022-4790

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✦ Synopsis

To determine the incidence and clinical signifance of micrometastases in the bone marrow of breast carcinoma patients, we performed an immunoalkaline phosphatase assay using anticytokeratin (AEI , AE3, MAK-6) and antiepithelial (1 13F1, 260F9, 3 17G5) antibodies on the bone marrow aspirates of 71 stage IV disease patients with either recurrent regional or distant metastases. Although we detected tumor cells within the bone marrow of 38% of these patients with this assay, no significant correlation was seen with patient's age, menopausal status, bone scan, bone marrow core histology, response to induction chemotherapy, number of metastatic sites, dominant site of metastasis, or subsequent clinical outcome. The clinical parameters that were associated with improved survival were one dominant site of metastatic disease and regional soft tissue recurrence without distant disease.

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## Background: Using cytokeratin (ck) as a histogenetic marker of epithelial tumor cells in the bone marrow of patients with primary breast carcinoma, a subgroup of patients with decreased survival can be identified. this study was designed to evaluate the frequency and prognostic relevance of such