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Detection of metabolites in rabbit brain by 13C NMR spectroscopy following administration of [1-13C]glucose

✍ Scribed by K. L. Behar; O. A. C. Petroff; J. W. Prichard; J. R. Alger; R. G. Shulman

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
606 KB
Volume
3
Category
Article
ISSN
0740-3194

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✦ Synopsis

Hdecoupled I3C NMR spectra (20.2 MHz) of the living rabbit brain were collected with a surface coil following the intravenous infusion of [1-"C]glucose. Within 15 min of infusion, the a and j 3 anomers of glucose were detected and, shortly thereafter, the carbon atoms at positions C4, C3, and C2 of glutamate and(or) glutamine. After reductions of inspired oxygen from 30 to 570, lactate C3 was detected. The intensity of the lactate resonance rose progressively during hypoxia and later fell during recovery with oxygen. The I3C fractional isotopic enrichment of arterial blood glucose was measured by 'H NMR providing information on the rate and extent of blood glucose labeling. 0 1986 Academic ha, Inc.

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