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Detection of low prevalence somatic mutations in solid tumors with ultra-deep targeted sequencing

✍ Scribed by Olivier Harismendy, Richard B Schwab, Lei Bao, Jeff Olson…

Book ID: 120701355
Publisher: BioMed Central
Year: 2011
Tongue: English
Weight: 352 KB
Volume: 12
Category: Article
ISSN: 1465-6906
DOI: 10.1186/gb-2011-12-12-r124

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## Communicated by Mark H. Paalman Mutations in the tumor-suppressor p53 gene TP53 are frequent in most human cancers including breast cancer. A new solid phase chemical cleavage of mismatch method (CCM) allowed rapid and efficient screening and analysis of the TP53 gene in DNA samples extracted