Detection of Low-level Expression of P-Glycoprotein in ACHN Renal Adenocarcinoma Cells
β Scribed by Kawamoto, Shogo ;Deguchi, Takashi ;Nezasa, Shinichi ;Yamada, Shinichiro ;Okano, Manabu ;Kawada, Yukimichi
- Book ID
- 108581197
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 1996
- Tongue
- English
- Weight
- 323 KB
- Volume
- 87
- Category
- Article
- ISSN
- 0910-5050
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## Abstract The purpose of this study was to investigate the correlation between mRNA and protein levels for Pβglycoprotein (Pβgp) expressed in various cell lines to validate the estimation of Pβgp activity from its mRNA levels. Pβgp expression levels in various cell monolayers, normal, Pβgpβinduce
Because reversal of multidrug resistance increases chemotoxicity, early detection of low P-glycoprotein expression is clinically relevant for justifying early treatment of those patients that might benefit most from reversal therapy. We elected to score Pglycoprotein in single tumor cells, because t