Detection of Ki-rasandp53gene mutations in tissue and pancreatic juice from pancreatic adenocarcinomas
β Scribed by Satoshi Kondoh; Miyuki Kaino; Satoshi Okita; Syomei Ryozawa; Tetsuji Akiyama; Kiwamu Okita
- Publisher
- Springer Japan
- Year
- 1998
- Tongue
- English
- Weight
- 325 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0944-1174
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## Abstract The gene encoding the cellβcycle regulatory protein p16, __CDKN2__, is localized on chromosome band 9p21. __CDKN2__ is frequently deleted or mutated in a variety of tumor cell lines, including pancreatic cancer cell lines and xenografts, as well as in some primary tumors. We examined 32
## BACKGROUND. It is often difficult to distinguish pancreatic carcinoma preoperatively from chronic pancreatitis. Therefore, we have developed a new method of detecting p53 immunoreactivity in cytologic material obtained by endoscopic retrograde pancreatic duct brushing (ERPDB). ## METHODS. Tw