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Detection of karyotype changes in interphase cells: oligonucleotide-primed in situ labelling versus fluorescence in situ hybridization

✍ Scribed by M. Werner; Ludwig Wilkens; Anette Nasarek; Joëlle Tchinda; Paul Komminoth

Book ID
106118611
Publisher
Springer
Year
1997
Tongue
English
Weight
308 KB
Volume
430
Category
Article
ISSN
1432-2307

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Fluorescence in situ hybridization was used in interphase cells of 30 ovarian carcinomas to detect numerical changes in copy number of I 3 different centromeres (I, 2.3,4,6.7,8, 10. I I, I 2, 17, 18, and X). Thirty-seven percent of samples ( I I /30) were near diploid and demonstrated only minor cha