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Detection of intratumoral DNA heterogeneity in primary lung cancer using a multiple sampling method


Book ID
121773298
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
150 KB
Volume
12
Category
Article
ISSN
0169-5002

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Mutations in the K-ras gene are often identified in lung tumors and are implicated in the development of lung cancer. We used a sensitive method to analyze low-fraction mutations occurring in codon 12 of the K-ras gene in 114 primary lung tumors, including 77 adenocarcinomas, 31 squamous cell carcin