Detection of interleukin-6 (IL-6) in human bone marrow myeloma cells by light and electron microscopy

Expression levels of gp130 in bone marro

Expression levels of gp130 in bone marrow stromal cells determine the magnitude of osteoclastogenic signals generated by IL-6-type cytokines

✍ Charles A. O'Brien; Song-Chang Lin; Teresita Bellido; Stavros C. Manolagas 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 151 KB 👁 1 views

-type cytokines stimulate osteoclast formation by activating the glycoprotein 130 (gp130) receptor subunit on stromal/osteoblastic cells, which in turn leads to signal transducer and activator of transcription 3 (STAT3)-mediated expression of receptor activator of NF-B ligand (RANKL). Based on evide