✦ LIBER ✦

Detection of human t lymphotropic virus type i tax gene in salivary gland epithelium from two patients with sjögren's syndrome

✍ Scribed by Xavier Mariette; Felix Agbalika; Marie-ThéRèSe Daniel; Michel Bisson; Philippe Lagrange; Jean-Claude Brouet; Frédéric Morinet

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 650 KB
Volume: 36
Category: Article
ISSN: 0004-3591
DOI: 10.1002/art.1780361015

No coin nor oath required. For personal study only.

✦ Synopsis

Objective. To investigate whether human T lymphotropic virus type I (HTLV-I) could be involved in the pathogenesis of Sjogren's syndrome (SS).

Methods. Labial salivary gland (LSG) biopsy specimens from 9 patients with SS (4 with primary SS and 5 with SS secondary to rheumatoid arthritis) and 9 controls were studied for the presence of the tax gene of HTLV-I using in situ hybridization, and for the presence of tux, gag, pol, and env genes of HTLV-I using the polymerase chain reaction (PCR). Testing for antibodies to HTLV-I and examination of lymphocytes on blood smears were performed to determine whether systemic viral infection was present.

Results. Using in situ hybridization and PCR, we detected the tax gene, but not the gag, pol, or env genes, of HTLV-I in LSG sections from 2 of 9 patients with SS

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