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Detection of human herpes virus type 6 DNA in precancerous lesions of the uterine cervix

✍ Scribed by Danh Tran-Thanh; Anita Koushik; Diane Provencher; Pierre Drouin; Josée Dubuc-Lissoir; Philippe Gauthier; Guy Allaire; Janet Kornegay; Eduardo Franco; François Coutlée

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
68 KB
Volume
68
Category
Article
ISSN
0146-6615

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✦ Synopsis

Abstract

Human herpes virus type 6 (HHV‐6) DNA has been suggested to be a cofactor to human papillomavirus (HPV) in cervical cancer. In a cross‐sectional study, we investigated the association between HHV‐6 DNA detected in cervical brushings and high‐grade squamous intraepithelial lesions (HSIL), while controlling for genital infection with 27 genotypes of HPV. Of the 320 women recruited from an oncologic gynecology clinic, 50 had invasive cervical cancer, 65 had HSIL, 80 had low‐grade squamous intraepithelial lesions (LSIL), and 125 were normal. Four of the seven HHV‐6‐positive women had HSIL. HHV‐6 was associated with HSIL after adjusting for age and socioeconomic status (odds ratio [OR] of 10.9, 95% confidence interval [CI]: 1.1–107.1). This association was no longer significant after controlling for HPV (OR = 6.4, 95% CI = 0.3–128.5). HHV‐6 was detected in cervical samples from women with precancerous and cancerous lesions of the cervix, but not significantly more frequently than in normal women. J. Med. Virol. 68:606–610, 2002. © 2002 Wiley‐Liss, Inc.

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