Detection of hepatitis C virus sequences in brain tissue obtained in recurrent hepatitis C after liver transplantation
โ Scribed by Hugo E. Vargas; Tomasz Laskus; Marek Radkowski; Jeff Wilkinson; Vijay Balan; David D. Douglas; M. Edwyn Harrison; David C. Mulligan; Kevin Olden; Debra Adair; Jorge Rakela
- Book ID
- 111723288
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 123 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1527-6465
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We compared tissue hepatitis C virus (HCV) RNA polymerase chain reaction quantification and HCV immunohistochemistry (IHC) to histology in biopsy tissues in order to differentiate between acute rejection and HCV hepatitis recurrence early after orthotopic liver transplantation (OLT). We analyzed the
## Identification of the hepatitis C virus-the main cause of posttransfusion and sporadic non -A, non-B hepatitisand the development of a diagnostic serological test have allowed us to study possible recurrence of this type of hepatitis after liver transplantation. Six of 34 consecutive transplant
1. Early recurrence of hepatitis C is universal. 2. Typical histopathologic features of hepatitis C virus (HCV) and acute allograft rejection (AAR) exist. 3. Early recurrent HCV may be differentiated from AAR. 4. Liver biopsy plays a role in diagnosing HCV and AAR. 5. Risk factors for recurrent HCV