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Detection of free radical intermediates during isoniazid and iproniazid metabolism by isolated rat hepatocytes

✍ Scribed by Emanuele Albano; Aldo Tomasi; Vanio Vannini; Mario U. Dianzani


Book ID
115778000
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
130 KB
Volume
34
Category
Article
ISSN
0006-2952

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Tamoxifen has been shown to be a potent liver carcinogen in rats, and generates covalent DNA adducts. Online high performance liquid chromatography/electrospray ionisation mass spectrometry (HPLC/ESI-MS) has been used to further study the metabolites of tamoxifen formed by rat liver microsomes in th