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Detection of familial defective apolipoprotein B-100 among patients clinically diagnosed with heterozygous familial hypercholesterolemia in maritime Canada

✍ Scribed by Barbara Morash; Duane L. Guernsey; Meng H. Tan; Gale Dempsey; Bassam A. Nassar


Book ID
107740558
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
964 KB
Volume
27
Category
Article
ISSN
0009-9120

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Prior to GC-MS analysis, samples (1 mL) were passed through a C-18 SPE cartridge (Supelco) preconditioned with ethyl acetate, 96% (v/v) ethanol and 10% (v/v) ethanol in sequence. Resveratrol was eluted with ethyl acetate and 1 mL was collected of which 1 I~L was injected. For samples with very low c

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it M/inchen Summary. Serum lipid concentrations of patients with familial defective apolipoprotein B-100 (FDB) show a high interindividual variability although the underlying defect is caused by a single point mutation. On the other hand, several genetic factors modulating serum cholesterol levels a