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Detection of Epstein-Barr virus in the brain by the polymerase chain reaction

✍ Scribed by Louise Pedneault; Ben Z. Katz; Dr. George Miller

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
914 KB
Volume
32
Category
Article
ISSN
0364-5134

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✦ Synopsis

Epstein-Barr virus (EBV) has been implicated in a variety of central nervous system syndromes. In a few well-studied patients, EBV has been detected by viral isolation or EBV D N A has been found by Southern hybridization analysis.

Using polymerase chain reaction, we evaluated brain biopsy specimens from 24 patients for the presence of EBV genomes. EBV D N A was found in brain specimens from 18 patients in whom presence of the virus in the brain was suspected clinically or on the basis of serological tests. Six patients had acquired immunodeficiency syndrome; 2 were kidney transplant recipients. Brain specimens from 4 patients with encephalitis due to other herpes group viruses and from a patient with metabolic encephalopathy were negative for EBV D N A as determined by polymerase chain reaction. The findings indicate a need to evaluate the role of EBV in diverse neurological syndxomes, especially those occurring in immunodeficient hosts.

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