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Detection of Epstein-Barr virus DNA in American Burkitt's lymphoma

✍ Scribed by Dr. John L. Ziegler; Maria Andersson; George Klein; Werner Henle

Publisher
John Wiley and Sons
Year
1976
Tongue
French
Weight
525 KB
Volume
17
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Twenty American patients with Burkitt's lymphoma (BL) were studied serologically and biochemically to detect an association with Epstein‐Barr virus (EBV). A wide range of antibody reactivities was encountered. Five patients had serorogical profiles similar to those of African patients with BL: one and possibly two of these patients harbored EBV‐DNA in their tumors. Fifteen patients had low or absent antibody to EBV: tumors from 10 of these patients lacked evidence of EBV‐DNA. An unexplained association between elevated antibody (≥1:80) to EBV virus capsid antigen (VCA) and a favorable prognosis was noted in this series; this prognostic observation requires further substantiation. Thus, it appears that EBV‐associated BL is inversely proportional to tumor endemicity. An etiological role for EBV in BL remains speculative.

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