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Detection of drug-induced conformational change of a transmembrane protein in lipid bilayers using site-directed spin labeling

✍ Scribed by Thomaston, Jessica L.; Nguyen, Phuong A.; Brown, Emily C.; Upshur, Mary Alice; Wang, Jun; DeGrado, William F.; Howard, Kathleen P.


Book ID
118766246
Publisher
Cold Spring Harbor Laboratory Press
Year
2012
Tongue
English
Weight
407 KB
Volume
22
Category
Article
ISSN
0961-8368

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## Abstract We have used the electron spin resonance (ESR) site‐directed spin‐labeling (SDSL) technique to examine the guanidine hydrochloride (Gdn‐HCl) induced denaturation of several sites along a transmembrane β‐strand located in the ferric enterobactin receptor, FepA. In addition, we have conti