𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Detection of distinct Epstein-Barr virus genotypes in NPC biopsies from Southern Chinese and Caucasians

✍ Scribed by Maria Li Lung; Garrick C. Chang

Publisher
John Wiley and Sons
Year
1992
Tongue
French
Weight
650 KB
Volume
52
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Using the polymerase chain reaction (PCR) to analyze paraffin sections from I 2 Caucasian patients, we detected only the prototype F Epstein-Barr virus (EBV) in 10 specimens from patients with nasopharyngeal carcinoma (NPC). This is in contrast to the higher frequency of association of "f" variants in NPC biopsies from Southern Chinese. The results of EBV genotyping support evidence that the EBV strains associated with NPC in the Southern Chinese population differ from those found in Caucasians. DNA sequencing confirmed that a simple point mutation is responsible for the restriction-fragmentlength polymorphism which distinguishes the prototype F virus from the "f" variant.

📜 SIMILAR VOLUMES

Comparison of polymerase chain reaction
Comparison of polymerase chain reaction and standard southern blotting for the detection of Epstein-barr virus DNA in various biopsy specimens
✍ Dr. Louise Pedneault; Ben Z. Katz 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 1007 KB

The sensitivity of the polymerase chain reaction (PCR) assay was compared to that of standard Southern blotting (SB) hybridization for detecting the presence of Epstein-Barr virus (EBV) genomes in biopsy samples from 43 patients with a variety of lymphoproliferative disorders. Two pairs of oligonucl

Direct detection of Epstein-Barr virus i
Direct detection of Epstein-Barr virus in peripheral blood and comparison of Epstein-Barr virus genotypes present in direct specimens and lymphoblastoid cell lines established from nasopharyngeal carcinoma patients and healthy carriers in Hong Kong
✍ Maria Li Lung; Wai Pang Lam; Kwok Hung Chan; Shaobing Li; Jonathan Sham; Damon C 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 French ⚖ 598 KB

## Abstract By means of a PCR assay, EBV was demonstrated directly in peripheral blood of previously infected individuals. The virus was detected in approximately 80% of specimens from EBV‐seropositive individuals, but not in cord‐blood lymphocytes by this method. When virus present in peripheral b

Distribution of Epstein–Barr virus genot
Distribution of Epstein–Barr virus genotypes in throat washings, sera, peripheral blood lymphocytes and in EBV positive tumor biopsies from Slovenian patients with nasopharyngeal carcinoma
✍ P. Klemenc; J. Marin; E. Šoba; N. Gale; S. Koren; P. Strojan 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 253 KB 👁 1 views

Nasopharyngeal carcinoma (NPC) is a malignancy closely associated with Epstein-Barr virus (EBV). It is prevalent among the Chinese of Southern China, whereas outside China, the position seems to be different. The aim of this study was to determine the distribution of EBV genotypes in the patients wi