All cancer staging systems seek to identify clinical and pathological features that can predict outcome or guide therapy. In particular, a non-invasive method for the early detection of disseminating disease would be of great interest. We investigated the use of cytokeratin genes expression to detec
Detection of disseminated tumour cells in blood and bone marrow samples of patients undergoing hepatic resection for metastasis of colorectal cancer
β Scribed by F. A. Vlems; J. H. S. Diepstra; C. J. A. Punt; M. J. L. Ligtenberg; I. M. H. A. Cornelissen; J. H. J. M. van Krieken; T. Wobbes; G. N. P. van Muijen; T. J. M. Ruers
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 109 KB
- Volume
- 90
- Category
- Article
- ISSN
- 0007-1323
- DOI
- 10.1002/bjs.4161
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Immunocytochemical detection (ICC) of isolated tumor cells in bone marrow (BM) is currently the most established method for monitoring early dissemination in epithelial cancer. However, the low sample size that can practically be analyzed restricts the sensitivity and reliability of the ICC method.
The aim of this study was to evaluate the changes of tumor cell contamination in bone marrow (BM) and peripheral blood (PB) during the clinical course of patients with advanced neuroblastoma by detecting tyrosine hydroxylase (TII) mRNA to clarify the appropriate source and time for harvesting hemato