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Detection of Chromosomal Aberrations by a Whole-Genome Microsatellite Screen

✍ Scribed by Marjorie J. Rosenberg; David Vaske; Christina E. Killoran; Yi Ning; David Wargowski; Louanne Hudgins; Cynthia J. Tifft; Jeanne Meck; Jan K. Blancato; Kenneth Rosenbaum; Richard M. Pauli; James Weber; Leslie G. Biesecker

Book ID
119769998
Publisher
American Society of Human Genetics
Year
2000
Tongue
English
Weight
341 KB
Volume
66
Category
Article
ISSN
0002-9297

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At least 50 per cent of all first-trimester spontaneous abortions are cytogenetically abnormal, including trisomy, monosomy X, triploidy, tetraploidy and structural chromosome anomalies. Traditionally, the detection of aneuploidy in fetal tissues is performed by tissue sampling, cell culturing, meta