Detection of cholangiocarcinoma in primary sclerosing cholangitis by positron emission tomography

✍ Scribed by Frieder Berr; Marcus Wiedmann; Joachim Mössner; Andrea Tannapfel; Frank Schmidt

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 36 KB
• Volume: 29
• Category: Article
• ISSN: 0270-9139
• DOI: 10.1002/hep.510290210

✦ Synopsis

During the 1995 heat wave in Chicago, the maximum temperature recorded was 40°C, although the heat index, an estimate of evaporative and radiative transfer of heat, was 48.3°C. 3 In developing countries, heat waves are accompanied by poor electricity supplies that disturb the working of electricity operated appliances meant for maintaining temperature at appropriate levels. 4 The inimical effects of high temperature and humidity 2,3 on different therapeutics as well as molecular biology reagents used to monitor antiviral therapy could be best tackled by stabilization against harsh environment. Efforts have been directed to stabilize live vaccines by incorporating trehalose, deuterium oxide, pirodavir, or compounds based on electrostatic interventions. 5 Availability of one-to two-step assay procedures that do not require costly equipment and trained personnel, would be vital for strengthening quality control on antihepatitis B or C viral therapeutics. Such assays would assist quantification of active ingredients of therapeutics in the premises of the physician prescribing various drugs. A semiquantitative, acetaminophen-specific spot test for screening quality of acetaminophen in the field has been very meritorious. 6 Full stabilized antihepatitis B or C viral therapeutic agents that would withstand environment rigors would ensure that every patient received full quantum of the prescribed therapeutic agent. Incorporation of stabilizers in molecular biol-ogy reagents would ensure full use of such reagents in the face of high humidity and temperature linked with impending global warming. 2,3 Surely, such therapeutics and diagnostic reagents against hepatitis B or C virus would eliminate erroneous laboratory data, poor therapeutic response, and emergence of resistant viral populations attributable to poor quality therapeutic agents.