Detection of cellular hypoxia by activation of the heat shock transcription factor (HSF): A method for hypoxic cell “marking” in vivo

In vivo activation of neural heat shock

In vivo activation of neural heat shock transcription factor HSF1 by a physiologically relevant increase in body temperature

✍ I.R. Brown; S.J. Rush 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 630 KB

Molecular mechanisms which underlie the heat shock response have commonly been analyzed using tissue culture systems, with less investigation of the intact mammal. In tissue culture, a temperature elevation of 5°C is required to activate mammalian heat shock transcription factor 1 (HSF1) to the DNA-