The human Polyomavirus BK (BKV) contains a hypervariable non-coding control region (NCCR), which regulates DNA replication and RNA transcription. The aim of this study was to characterize BKV NCCR-variants in kidney biopsies and urine samples from renal-transplant patients and to see whether there i
Detection of BK virus in urine from renal transplant subjects by mass spectrometry
โ Scribed by Rebecca Konietzny, Roman Fischer, Nicola Ternette, Cynthia A Wright, Ben W Turney, Aron Chakera, David Hughes, Benedikt M Kessler, Chris W Pugh
- Book ID
- 119906268
- Publisher
- BioMed Central
- Year
- 2012
- Tongue
- English
- Weight
- 350 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1542-6416
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## Abstract BK virus associated nephropathy occurs in approximately 5% of renal transplant recipients. Quantitation of BKV DNA in serum/plasma early in the course of disease has been suggested to be an important diagnostic tool for polymavirusโassociated nephropathy (PVAN). The aim of this study wa
## Abstract Polyomavirusโassociated nephropathy (PVAN) is a major complication that occurs after renal transplantation and is induced by reactivation of the human polyomavirus BK (BKV). The structure of the viral capsid protein 1 (VP1) is characterized by the presence of external loops, BC, DE, EF,