Detection of ATM gene deletion/duplication by multiplex ligation-dependant probe amplification in childhood lymphoid malignancies: A report from the Children's Oncology Group
✍ Scribed by Fabienne Gumy-Pause; Hulya Ozsahin; Mary Khoshbeen-Boudal; David R. Betts; Philippe Maillet; André-Pascal Sappino
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 391 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0145-2126
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✦ Synopsis
ATM gene alterations have been described in various lymphoproliferative malignancies suggesting that ATM contributes to lymphomagenesis. Using multiplex ligation-dependant probe amplification (MLPA), we screened 61 childhood lymphoid malignancies for ATM genomic deletion/duplication. Five samples were found to have a complete deletion or duplication. All the three deletions were found in B-precursor ALL (15%), two were submicroscopic, not detected by standard cytogenetic studies. These observations indicate that as in adult ALL, complete ATM submicroscopic deletion is frequent in childhood B-precursor ALL. As previously hypothesized, these results suggest that ATM may act as a tumor suppressor gene in the pathogenesis of childhood B-precursor ALL.