## Abstract Because of widely differing reports on the significance of IgM antiβHBc in chronic hepatitis B virus (HBV) infection, paired sera and liver biopsies from 49 patients with chronic HBV infection were analysed for serum IgM antiβHBc, HBsAg titre, HBeAgiantiβHBe, HBV DNA, serum aspartate tr
Detection of Anti-HBc IgM Following Prednisone Treatment in Patients with Chronic Active Hepatitis B Virus Infection
β Scribed by Marek J. Nowicki; Myron J. Tong; Prem V. Nair; Douglas Stevenson
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 536 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0270-9139
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Sera from four groups of patients with different serologic markers of HBV infection were examined for HBV DNA using molecular hybridization technique and for IgM class anti-HBc using an ELISA based on the antibody capture principle. Results of HBV DNA assay were generally in good agreement with the
## Abstract Serum antiβHBc IgM titres were monitored monthly by a semiquantitative method in 14 children with HBeAg positive chronic hepatitis B followed up for 18β65 months. All patients, but one, were treated with alfaβinterferon (IFN) at different times. On the whole, 12 flareβup episodes were o
Serum IgM anti-HBc was determined in 135 chronic HBsAg carriers with various categories of histological activity on liver biopsy and hepatitis B serological profile. Thirty-three patients were treated with interferon-a to investigate the correlation between serum IgM anti-HBc with histological activ
Fourteen chimpanzees were inoculated with pre- and posttreatment sera from seven patients with persistent hepatitis B virus infection and chronic hepatitis who had permanent responses of their infection to treatment with interferon and/or adenine arabinoside. Inoculation of pretreatment serum at a d
## Abstract Peripheral blood mononuclear cells (PBMC) from 25 patients with chronic hepatitis B were tested for the presence of free monomeric hepatitis B virus (HBV) DNA migrating as a single 3.2 Kb band by Southern blot analysis. The PBMC were cultured for 7 days in the presence of phytohemagglut