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Detection of an interferon antagonist, sarcolectin, in human sarcomas and muscles

✍ Scribed by Pan Hong Jiang; Françoise Chany-Fournier; Madeleine Sarragne; Anne Grégoire; Charles Chany

Book ID: 102866135
Publisher: John Wiley and Sons
Year: 1984
Tongue: French
Weight: 805 KB
Volume: 34
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910340507

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✦ Synopsis

In a variety of human sarcomas we detected the presence of a sarcolectin which reversed an established antiviral protection induced by interferon (IFN). For the same protein concentration, this biological activity was significantly increased when compared to that of normal muscles. All the biological characteristics were comparable to those of a sarcolectin found in hamster tissues; namely the capacity to agglutinate cells and its inhibition by specific sugars, migration in sodium dodecyl sulfate gel, and pepsin, heat and sodium dodecyl sulfate stability. Except for its anti-IFN function and cell agglutinating activity, the biological significances of this sarcolectin is presently poorly understood.

Guest worker from the National Vaccine and Serum Institute, Beijing, China.

*To whom reprint requests should be addressed.

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