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Detection of Amadori compounds by capillary electrophoresis coupled to tandem mass spectrometry

✍ Scribed by Jörg Hau; Stéphanie Devaud; Imre Blank

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
181 KB
Volume
25
Category
Article
ISSN
0173-0835

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✦ Synopsis

Abstract

Capillary electrophoresis coupled to mass spectrometry (CE‐MS) is reported for the first time as an alternative and powerful analytical method for the characterization and monitoring of N‐substituted 1‐amino‐1‐deoxyketoses (Amadori compounds). It allows rapid separation and identification of Amadori compounds, while benefiting from the well‐known advantages of MS, such as specificity and sensitivity. Amadori compounds of several amino acids, such as glycine, valine, isoleucine, methionine, proline, and phenylalanine, as well as a cysteine‐derived compound, were separated and/or discriminated using CE‐MS/MS under standard conditions. The technique may also be useful to study the stability and degradation kinetics of other labile charged Maillard intermediates that play an important role in food and medical science.

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