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Detection of a point mutation in sphingolipid activator protein-1 mRNA in patients with a variant form of metachromatic leukodystrophy

✍ Scribed by Mohammad A. Rafi; Xun-Ling Zhang; Gregory DeGala; David A. Wenger


Book ID
115763067
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
645 KB
Volume
166
Category
Article
ISSN
0006-291X

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A microtitre format point mutation assay
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## Abstract An assay for the analysis of point mutations in DNA fragments amplified by the polymerase chain reaction is described. The method was applied to the analysis of mutations leading to single amino acid changes in the reverse transcriptase gene of human immunodeficiency virus type‐1 that a