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Detection of a Biomarker for Alzheimer's Disease from Synthetic and Clinical Samples Using a Nanoscale Optical Biosensor

✍ Scribed by Haes, Amanda J.; Chang, Lei; Klein, William L.; Van Duyne, Richard P.


Book ID
120205701
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
300 KB
Volume
127
Category
Article
ISSN
0002-7863

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## Abstract Alzheimer's disease (AD) differs from other forms of dementia in its relation to amyloid Ξ² peptide (AΞ²). AΞ², a proteolytic product of amyloid precursor proteins (APP), has a toxic effect on neuronal cells, which involves perturbation of their Ca^2+^ homeostasis. This effect implies that