Detection of 6q deletions in breast carcinoma cell lines by fluorescence in situ hybridization
โ Scribed by Yanming Zhang; Peter Matthiesen; Reiner Siebert; Svetlana Harder; Michael Theile; Siegfried Scherneck; B. Schlegelberger
- Book ID
- 106137102
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 227 KB
- Volume
- 103
- Category
- Article
- ISSN
- 0340-6717
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Deletions of the long arm of chromosome 6 (6q) are among the most frequent chromosome aberrations in malignant lymphomas and often occur as secondary changes in addition to typical translocations, such as t(14;18). Using fluorescence in situ hybridization (FISH) with two YAC probes hybridizing to 6q
An unambiguous and rapid characterization of amplified DNA sequences in tumor cells is important for the understanding of neoplastic progression. This study was conducted t o evaluate the potential of fluorescence in situ hybridization (FISH) t o identify such amplified DNA sequences in human tumor
## Abstract The translocation t(12;15)(p13;q25), in which the __ETV6__ gene from chromosome 12 is rearranged with the __NTRK3__ gene from chromosome 15, has recently been identified in secretory breast carcinoma (SBC). This fusion gene was initially described in congenital fibrosarcoma and congenit