Detection of 13C-labeled metabolites in the in vivo canine heart by B1 insensitive heteronuclear coherent polarization transfer and comparison of signal enhancement with NOE
✍ Scribed by Haoran Wei; Hellmut Merkle; Ya Xu; Jutta Ellermann; Kevin Sipprell; Kǎmil Uǧurbil
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 385 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
Abstract
A recently developed adiabatic coherent polarization transfer enhancement technique [H. Merkle, H. Wei, M. Garwood, K. Uǧurbil. J. Magn. Reson. 99, 480–494 (1992)] was employed to perform ^13^C spectroscopy in the intact canine heart in vivo during [2‐^13^C]‐acetate infusion into the left descending coronary artery; the results were compared with ^13^C spectra obtained with conventionally employed nuclear Overhauser enhancement. The results demonstrate that both methods can be performed by using surface coils to obtain in vivo ^13^C spectra and that coherent polarization transfer provides better enhancement than NOE for [2‐^13^C]‐acetate but not for short T~2~ compounds.