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Detection limits of DNA copy number alterations in heterogeneous cell populations

✍ Scribed by Oscar Krijgsman, Daniëlle Israeli, Hendrik F. van Essen, Paul P. Eijk…


Book ID
120724094
Publisher
Springer Netherlands
Year
2012
Tongue
English
Weight
768 KB
Volume
36
Category
Article
ISSN
1570-5870

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## Abstract Identification of the genetic alterations that occur in tumors is an important approach to understanding tumorigenesis. We have used comparative genomic hybridization (CGH), a novel molecular cytogenetic method, to identify the gross DNA copy number changes that commonly occur in small