Detection by Complementation of Defective or Uninducible (Herpes Simplex Type 1) Virus Genomes Latent in Human Ganglia
โ Scribed by S. Moira Brown, J. H. Subak-Sharpe, K. G. Warren, Z. Wroblewska and H. Koprowski
- Book ID
- 123655726
- Publisher
- National Academy of Sciences
- Year
- 1979
- Tongue
- English
- Weight
- 938 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0027-8424
- DOI
- 10.2307/69387
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Clinical data indicate that the recurring herpes simplex virus (HSV) from oro-labial lesions is HSV subtype 1 and that the virus from genital lesions is HSV-2. This suggests that HSV-1 and HSV-2 reside in latent forms in the trigeminal ganglia and sacral ganglia, respectively. However, the distribut
Herpes simplex virus type 1 (HSV-1) DNA was extracted from human trigeminal ganglia of 121 cadavers aged between 3 months and 94 years, and its PCR amplification was performed for the RL2 HSV-1 sequence using two pairs of primers. The HSV-1 DNA was detected in 74 of 121 patients (61%); 70/74 bilater