Detection and Treatment of Cerebral Hypoxia Key to Avoiding Intraoperative Brain Injuries

The mitochondrial permeability transitio

The mitochondrial permeability transition pore provides a key to the diagnosis and treatment of traumatic brain injury

✍ Richard L. Veech; C. Robert Valeri; Theodore B. VanItallie 📂 Article 📅 2012 🏛 John Wiley and Sons 🌐 English ⚖ 506 KB

## Abstract The pathological consequences of traumatic head injury result largely from the opening of the mitochondrial permeability transition pore (mPTP). The mPTP opens due to a decrease in brain phosphorylation energy resulting in a further decrease in brain ATP production and a measurable incr