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Detection and characterisation of two missense mutations at a cleavage site in the factor VIII light chain

✍ Scribed by R. Schwaab; M. Ludwig; L. Kochhan; J. Oldenburg; J.H. McVey; H. Egli; H.H. Brackmann; K. Olek


Book ID
119038022
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
733 KB
Volume
61
Category
Article
ISSN
0049-3848

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The 3' portion of the coagulation factor VII gene, containing the activation and serine protease domains, was investigated in four subjects with factor VII deficiency by temperature gradient gel electrophoresis and sequencing of polymerase chain reaction (PCR) products. Molecules displaying an alter