Detection and analysis of recognition and selection in the immune response

✍ Scribed by Charles DeLisi

• Publisher: Springer
• Year: 1977
• Tongue: English
• Weight: 771 KB
• Volume: 39
• Category: Article
• ISSN: 1522-9602
• DOI: 10.1016/s0092-8240(77)80050-5

✦ Synopsis

Some theoretical requirements for the vahd use of hemolync plaque inhibihon as a method for studying cellular selecnon and recognition in an immune response are reviewed. Aside from providing a rational basis for the use of this technique, the theory resolves a gro-~,un~ body of apparently conflicting results on the affinity regulation of IgM secreting cells and can also be used to deduce structural (m particular, morphological) features of the IgM molecule. The diverse predictions of the theory are examined in hght of experimental results and find support in a wide data base. Additional specific experiments are proposed which can be used in conjunction with the theory to help clarify the relation between cellular proliferation and maturation.