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Detection and activation of human Vα24+ natural killer T cells using α-galactosyl ceramide-pulsed dendritic cells

✍ Scribed by Shin-ichiro Fujii; Kanako Shimizu; Ralph M. Steinman; Madhav V. Dhodapkar


Book ID
114051228
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
359 KB
Volume
272
Category
Article
ISSN
0022-1759

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## Abstract Human invariant Vα24^+^ natural killer T (NKT) cells display potent antitumor activity upon stimulation. Activation of endogenous Vα24^+^ NKT cells would be one strategy for the treatment of cancer patients. For example, dendritic cells (DCs) loaded with a glycolipid NKT cell ligand, α‐