✦ LIBER ✦

Detecting S-adenosyl-l-methionine-induced conformational change of a histone methyltransferase using a homogeneous time-resolved fluorescence-based binding assay

✍ Scribed by Ying Lin; Hong Fan; Mathias Frederiksen; Kehao Zhao; Lei Jiang; Zhaofu Wang; Shaolian Zhou; Weihui Guo; Jun Gao; Shu Li; Edmund Harrington; Peter Meier; Clemens Scheufler; Yao-Chang Xu; Peter Atadja; Chris Lu; En Li; X. Justin Gu

Book ID: 113412401
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 916 KB
Volume: 423
Category: Article
ISSN: 0003-2697
DOI: 10.1016/j.ab.2012.01.019

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Development of a Binding Assay for p53/H

Development of a Binding Assay for p53/HDM2 by Using Homogeneous Time-Resolved Fluorescence

✍ Stefanie A. Kane; Catherine A. Fleener; Yun S. Zhang; Lenora J. Davis; Amy L. Mu 📂 Article 📅 2000 🏛 Elsevier Science 🌐 English ⚖ 127 KB

The p53 tumor suppressor protein is activated and stabilized in response to DNA damage, resulting in cell cycle arrest or apoptosis. HMD2 is a negative regulator of p53. Binding of p53 by HDM2 traffics p53 from the nucleus to the cytoplasm where it is recognized and targeted for ubiquitin-mediated d