Under acidic conditions the enantiomers of Tröger's base 1 (2,8-dimethyl-6 H,12 H-5,11-methanodibenzo[b,f][1,5]diazozine) are subject to enantiomerization. During enantioselective dynamic electrokinetic chromatography using 10 mM hydroxypropyl-beta-cyclodextrin as the chiral mobile phase additive in
Detailed study of Tröger's base separation by SMB process
✍ Scribed by Kathleen Mihlbachler; Andreas Seidel-Morgenstern; Georges Guiochon
- Publisher
- American Institute of Chemical Engineers
- Year
- 2004
- Tongue
- English
- Weight
- 202 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0001-1541
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The ' H and '% NMR spectra of 15 modified representatives of Troger's base were recorded and the corresponding signals assigned. In 'H NMR, the appearance of the AABB'CC'(XX) system, after irradiation of H,(H,), is deceptively simple and should not be first-order analysed. The 13C chemical shifts an
The 1H NMR spectra of a series of acridine-derived Tro gerÏs base analogs substituted at various positions were registered. Also the 1H NMR characteristics of the Ðrst heterocyclic asymmetric Tro gerÏs base analog constituted of one acridine and one phenanthroline nucleus with the two corresponding