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Desymmetrization of cyclohexadienones via cinchonine derived thiourea-catalyzed enantioselective aza-Michael reaction and total synthesis of (-)-Mesembrine

✍ Scribed by Gu, Qing; You, Shu-Li

Book ID
118189172
Publisher
The Royal Society of Chemistry
Year
2011
Tongue
English
Weight
152 KB
Volume
2
Category
Article
ISSN
2041-6520

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Asymmetric Synthesis of Polyfunctionalized Pyrrolidines via a Thiourea Catalyzed Domino Mannich/Aza-Michael Reaction
✍ Dieter Enders; Dominik P. Göddertz; Christian Beceño; Gerhard Raabe 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 230 KB 👁 2 views

## Abstract The domino Mannich/aza‐Michael reaction of γ‐malonate‐substituted α,β‐unsaturated esters with __N__‐protected arylaldimines has been achieved. Catalyzed by bifunctional thioureas, 2,5‐__cis__‐configured polysubstituted pyrrolidines are obtained in good to excellent yields (76–99%), enan