Destructive weighted Poisson cure rate models
✍ Scribed by Josemar Rodrigues; Mário de Castro; N. Balakrishnan; Vicente G. Cancho
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 290 KB
- Volume
- 17
- Category
- Article
- ISSN
- 1380-7870
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We extend the modified Gompertz hazard function, first used by Cantor and Shuster for estimation of cure rates from pediatric clinical trials, by including covariate effects. The extended model provides a convenient method for estimation of the cure rate as a function of treatments and covariates.
Cure rate estimation is an important issue in clinical trials for diseases such as lymphoma and breast cancer and mixture models are the main statistical methods. In the last decade, mixture models under different distributions, such as exponential, Weibull, log-normal and Gompertz, have been discus