Recent evidence suggests that the β-catenin gene (CTNNB1) acts as an oncogene, and some human colon tumors with an intact APC gene have activating mutations in CTNNB1. In this study, mutations in the region corresponding to N-terminal phosphorylation sites (codons 1-51) of the rat Ctnnb1 gene were i
✦ LIBER ✦
Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis
✍ Scribed by Yankner, Bruce A.; Zhang, Zhuohua; Hartmann, Henrike; Minh Do, Viet; Abramowski, Dorothee; Sturchler-Pierrat, Christine; Staufenbiel, Matthias; Sommer, Bernd; van de Wetering, Marc; Clevers, Hans; Saftig, Paul; De Strooper, Bart; He, Xi
- Book ID
- 109708768
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 707 KB
- Volume
- 395
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/27208
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Frequent mutations of the rat β-catenin
✍
Masumi Suzui; Toshikazu Ushijima; Roderick H. Dashwood; Naoki Yoshimi; Takashi S
📂
Article
📅
1999
🏛
John Wiley and Sons
🌐
English
⚖ 172 KB
👁 1 views
Constitutive activation of the Wnt signa
✍
Noriaki Sunaga; Takashi Kohno; Frank T. Kolligs; Eric R. Fearon; Ryusei Saito; J
📂
Article
📅
2001
🏛
John Wiley and Sons
🌐
English
⚖ 135 KB
👁 1 views
17β-Estradiol Reduces Neuronal Apoptosis
✍
M.T. Corasaniti; D. Amantea; R. Russo; S. Piccirilli; A. Leta; M. Corazzari; G.
📂
Article
📅
2005
🏛
Elsevier Science
🌐
English
⚖ 369 KB
P1-113: Accecelerated Aβ plaque formatio
✍
Takahiro Suemoto; Takashi Saito; Jiro Takano; Yukio Matsuba; Naomi Yamazaki; Mas
📂
Article
📅
2008
🏛
Elsevier Science
🌐
English
⚖ 56 KB
Cytoplasmic and nuclear accumulation of
✍
Katarina Omholt; Anton Platz; Ulrik Ringborg; Johan Hansson
📂
Article
📅
2001
🏛
John Wiley and Sons
🌐
French
⚖ 295 KB
Beta-catenin plays an important role in the Wnt signaling pathway by activating T-cell factor (Tcf)/lymphoid enhancer factor (Lef)-regulated gene transcription. The level of beta-catenin is regulated through GSK-3beta phosphorylation of specific serine and threonine residues, all of which are encode
Cell cycle-driven neuronal apoptosis spe
✍
Bilal Malik; Antonio Currais; Salvador Soriano
📂
Article
📅
2008
🏛
John Wiley and Sons
🌐
English
⚖ 221 KB