Desorption–ionization mass spectrometry on porous silicon
✍ Scribed by Buriak, Jillian M.; Wei, Jing; Siuzdak, Gary
- Book ID
- 109638282
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 302 KB
- Volume
- 399
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/20400
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✦ Synopsis
Many liquids cooled to low temperatures form glasses (amorphous solids) instead of crystals. As the glass transition is approached, molecules become localized and relaxation times increase by many orders of magnitude 1 . Many features of this 'slowing down' are reasonably well described 2 by the modecoupling theory of supercooled liquids 3 . The ideal form of this theory predicts a dynamical critical temperature T c at which the
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## Abstract Desorption/ionization on porous silicon (DIOS) is a form of laser desorption mass spectrometry that allows for the direct mass analysis of a variety of analytes without the addition of organic matrix. Protocols are described for the direct analysis of exocrine tissue and single neurons
## Abstract Desorption/ionization on porous silicon (DIOS) is a very useful technique in the case of small molecular weight compounds, compared to the matrix‐assisted laser desorption ionization (MALDI). This is because MALDI generates matrix‐related ions that overlap with the mass range of interes