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Desorption of human serum albumin and human fibrinogen from the poly(3-hydroxybutyrate) surface

✍ Scribed by A. L. Iordanskii; E. V. Dmitriev; P. P. Kamaev; G. E. Zaikov

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 131 KB
Volume: 74
Category: Article
ISSN: 0021-8995
DOI: 10.1002/(sici)1097-4628(19991017)74:3<595::aid-app13>3.0.co;2-u

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✦ Synopsis

The protein desorption of human serum albumin and human fibrinogen from the surface of poly(3-hydroxybutyrate) films was studied using ATR-FTIR spectroscopy. The diffusion model for reversible and irreversible sandwiched layers was confirmed. The reversible ratio (ratio of reversible adsorbed concentration to irreversible adsorbed concentration as a function of time allows for a suggestion as to a kinetic model of the initial stage of thromb formation. The parameters of adsorption/desorption for both proteins are compared. The reversible ratio of plasma protein adsorption is proposed as a quantitative criterion of thromb-resistance behavior for polymers in biomedicine; namely, controlled drug release vehicles, artificial vessels, magistrals, reservoirs for blood storage, and surgical threads, especially. The mechanism of interaction of protein molecules with poly(3hydroxybutyrate (PHB) macromolecules is discussed.

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