Desmopressin (DDAVP) treatment in adult sleep-related enuresis

✍ Scribed by Gregory Katz; Baruch Spivak; Roberto Mester; Alex Grinshpoon; Abraham Weizman

• Book ID: 101280404
• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 76 KB
• Volume: 12
• Category: Article
• ISSN: 0885-6222
• DOI: 10.1002/(sici)1099-1077(199709/10)12:5<505::aid-hup916>3.0.co;2-a

✦ Synopsis

In an open prospective study we investigated the ecacy of intranasal administration of 1-desamino-8-D-arginine vasopressin (DDAVP) in enuretic adults during military service. Twelve male enuretic soldiers aged 18±19 years (18Á9 +0Á5 years), with a history of resistance to tricyclic antidepressant treatment and to behavioural therapy, were included in the study. Patients were treated with 20±40 mg (bedtime dose) DDAVP. A signi®cant decrease in the frequency of enuresis was demonstrated (3Á4 + 4Á3 versus baseline of 8Á2 +3Á3 days, p 0Á01). Four patients achieved complete dryness and four patients achieved partial response. It seems that intranasal DDAVP can be an eective and safe treatment in young adult sleep-related enuresis.