Designs of Superiority and Noninferiority Trials for Binary Responses are Noninterchangeable

A comparison of the randomized play-the-

A comparison of the randomized play-the-winner rule and the triangular test for clinical trials with binary responses

✍ D. S. Coad; William F. Rosenberger 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 91 KB 👁 2 views

We consider a clinical trial model comparing an experimental treatment with a control treatment when the responses are binary. For fixed significance level and power, we compare the expected number of treatment failures for two designsthe randomized play-the-winner rule and the triangular test. The