The knowledge of the solubility of pharmaceuticals in pure solvents and solvent mixtures is crucial for designing the crystallization process of drug substances. The first step in finding optimal crystallization conditions is usually a solvent screening. Since experiments are very time consuming, a
Designs for mixture and process variables applied in tablet formulations
โ Scribed by C.A.A. Duineveld; A.K. Smilde; D.A. Doornbos
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 969 KB
- Volume
- 277
- Category
- Article
- ISSN
- 0003-2670
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โฆ Synopsis
AbStIWt
Although there are several methods for the construction of a design for process variables and mixture variables, there are not very many methods which are suitable to combine mixture and process variables in one design. Some of the methods which are feasible will be shown. These methods will be compared in a design space consisting of three mixture variables and two process variables. This comparison will be made with criteria from the theory of optimal design and with the aid of experimental data.
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