Designing immunotoxins for cancer therapy
โ Scribed by Christopher A. Pennell; Heidi A. Erickson
- Book ID
- 111639115
- Publisher
- Springer-Verlag
- Year
- 2002
- Tongue
- English
- Weight
- 159 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0257-277X
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Immunotoxins are composed of a protein toxin connected to a binding ligand such as an antibody or growth factor. These molecules bind to surface antigens (which internalize) and kill cells by catalytic inhibition of protein synthesis within the cell cytosol. Immunotoxins have recently been tested cl
Rationally designed anticancer agents that target cell-surface antigens or receptors represent a promising approach for treating cancer patients. However, antibodies that bind these targets are often, by themselves, non-cytotoxic. By attaching potent toxins we can dramatically improve the clinical u