Incorporating target heterogeneity in dr
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Adrian Velazquez-Campoy; Ernesto Freire
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Article
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2001
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John Wiley and Sons
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English
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Traditionally, structure-based drug design has been predicated on the idea of the lock-and-key hypothesis, i.e., the ideal drug should have a structure that complements the target site structurally and energetically. The implementation of this idea has lead to the development of drug molecules that