Designed double-strand DNA cleavage with chelate-appended porphyrins

✍ Scribed by John T. Groves; Akio Matsunaga

• Book ID: 104364622
• Publisher: Elsevier Science
• Year: 1996
• Tongue: English
• Weight: 334 KB
• Volume: 6
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/s0960-894x(96)00281-8

✦ Synopsis

The first example of DNA double-strand cleavage mediated by a synthetic porphyrin is described. Two new porphyrins, each with two metal eomplexing appendages, were shown to mediate the oxidative double-strand cleavage ofpBR322 plasmid DNA.